2016亚太茶产业研讨会，由台北医学大学医学院医学科学研究所所长何元顺博士发表：普洱茶帮助衰减因吸烟导致的泡沫细胞形成透过抑制a9-烟碱乙酰胆碱受主在单核细胞中的表现：体外研究Pu-erh tea attenuate smoking-induced foam cell formation through inhibition of the 9-nicotinic-acetylcholine receptor expression in monocytes: an ex vivo study

论文研究重点

•90%的α-9尼古丁受主（α9-nAchR）在单核细胞中减少表现，使减少粥状动脉硬化风险。

•在重度吸烟者的单核细胞中，观察到尼古丁会诱发细胞形成泡沫细胞。

•茶叶可以降低单核细胞中，由尼古丁引起α-9尼古丁受主（α9-nAchR）细胞的泡沫化。

•饮茶可以有效的降低由吸烟所导致动脉粥样硬化的单核细胞初始泡沫化。

Highlights

•Nearly 90% of theα9-nAchR protein was exclusively expressed in monocytes.

•Nicotine-induced foam-cell formation was significantly observed in monocytes from heavy smokers.

•Tea consumption downregulated the monocyticα9-nAchR expression which that causes resist nicotine-induced foam cell formation.

•Tea-drinking effectively attenuates the initial step（foam-cell formation）of smoking-induced atherosclerosis in circulating monocytes.

整体来说，香烟中的尼古丁会增加白血球单核细胞「α-9尼古丁受主」表现，进而促进泡沫细胞形成、增加粥状动脉硬化风险，而普洱茶可以减少抽烟者的α-9尼古丁受主表现，并减少粥状动脉硬化发生。